{"id":233646,"date":"2026-03-19T07:28:41","date_gmt":"2026-03-19T12:28:41","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/psoriasis-modulates-inflammatory-bowel-disease-risk-and-intestinal-epithelium-lipid-metabolism-via-il-1%ce%b2-producing-macrophages"},"modified":"2026-03-19T07:28:41","modified_gmt":"2026-03-19T12:28:41","slug":"psoriasis-modulates-inflammatory-bowel-disease-risk-and-intestinal-epithelium-lipid-metabolism-via-il-1%ce%b2-producing-macrophages","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/psoriasis-modulates-inflammatory-bowel-disease-risk-and-intestinal-epithelium-lipid-metabolism-via-il-1%ce%b2-producing-macrophages","title":{"rendered":"Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1\u03b2-producing macrophages"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/psoriasis-modulates-inflammatory-bowel-disease-risk-and-intestinal-epithelium-lipid-metabolism-via-il-1ceb2-producing-macrophages.jpg\"><\/a><\/p>\n<p>Online now: Wu et al. reveal an inverse relationship between psoriasis severity and postprandial APOB48 levels in humans. Using a newly developed photoconvertible APOB knockin mouse and intestinal organoids, they show that IL-1\u03b2-producing macrophages drive APOB degradation and epithelial lipid accumulation, uncovering a novel link between psoriasis and intestinal inflammation comorbidity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Online now: Wu et al. reveal an inverse relationship between psoriasis severity and postprandial APOB48 levels in humans. Using a newly developed photoconvertible APOB knockin mouse and intestinal organoids, they show that IL-1\u03b2-producing macrophages drive APOB degradation and epithelial lipid accumulation, uncovering a novel link between psoriasis and intestinal inflammation comorbidity.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233646","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233646"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233646\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233646"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233646"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}