{"id":233601,"date":"2026-03-18T23:17:26","date_gmt":"2026-03-19T04:17:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/a-ptpn23-dependent-escrt-pathway-is-essential-for-constitutive-secretion-in-mammalian-cells"},"modified":"2026-03-18T23:17:26","modified_gmt":"2026-03-19T04:17:26","slug":"a-ptpn23-dependent-escrt-pathway-is-essential-for-constitutive-secretion-in-mammalian-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/a-ptpn23-dependent-escrt-pathway-is-essential-for-constitutive-secretion-in-mammalian-cells","title":{"rendered":"A PTPN23-dependent ESCRT pathway is essential for constitutive secretion in mammalian cells"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-ptpn23-dependent-escrt-pathway-is-essential-for-constitutive-secretion-in-mammalian-cells.gif\"><\/a><\/p>\n<p>Dani\u00e8le Stalder, Concei\u00e7\u00e3o Pereira, David C. Gershlick et al. (University of Cambridge) uncover new regulators of Golgi-to-plasma membrane transport, showing that a PTPN23-dependent ESCRT pathway is essential for secretion of membrane &amp; soluble cargoes, including hormones &amp; antibodies.<\/p>\n<hr>\n<p>Stalder and Pereira et al. combine affinity isolation of post-Golgi carriers, mass spectrometry, and a pooled CRISPR-KO screen to uncover new regulators of.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dani\u00e8le Stalder, Concei\u00e7\u00e3o Pereira, David C. Gershlick et al. (University of Cambridge) uncover new regulators of Golgi-to-plasma membrane transport, showing that a PTPN23-dependent ESCRT pathway is essential for secretion of membrane &amp; soluble cargoes, including hormones &amp; antibodies. Stalder and Pereira et al. combine affinity isolation of post-Golgi carriers, mass spectrometry, and a pooled CRISPR-KO [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233601","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233601"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233601\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}