{"id":233522,"date":"2026-03-17T22:23:14","date_gmt":"2026-03-18T03:23:14","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/deep-learning-based-de-novo-discovery-and-design-of-therapeutics-that-reverse-disease-associated-transcriptional-phenotypes"},"modified":"2026-03-17T22:23:14","modified_gmt":"2026-03-18T03:23:14","slug":"deep-learning-based-de-novo-discovery-and-design-of-therapeutics-that-reverse-disease-associated-transcriptional-phenotypes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/deep-learning-based-de-novo-discovery-and-design-of-therapeutics-that-reverse-disease-associated-transcriptional-phenotypes","title":{"rendered":"Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/deep-learning-based-de-novo-discovery-and-design-of-therapeutics-that-reverse-disease-associated-transcriptional-phenotypes2.jpg\"><\/a><\/p>\n<p>Bulk and single-cell transcriptomics are widely used to characterize diseases and cellular states but remain underexplored for <i>de novo<\/i> drug discovery. Here, we present a strategy to screen and optimize compounds by matching disease transcriptomic profiles with compound-induced transcriptomic features predicted from chemical structures using a deep-learning model.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bulk and single-cell transcriptomics are widely used to characterize diseases and cellular states but remain underexplored for de novo drug discovery. Here, we present a strategy to screen and optimize compounds by matching disease transcriptomic profiles with compound-induced transcriptomic features predicted from chemical structures using a deep-learning model.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,6],"tags":[],"class_list":["post-233522","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233522"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233522\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233522"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233522"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}