{"id":233484,"date":"2026-03-17T06:26:20","date_gmt":"2026-03-17T11:26:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/dual-roles-of-usp39-in-stabilizing-pb2-and-orchestrating-ribonucleoprotein-assembly-drive-h5-influenza-virus-replication-and-pathogenicity"},"modified":"2026-03-17T06:26:20","modified_gmt":"2026-03-17T11:26:20","slug":"dual-roles-of-usp39-in-stabilizing-pb2-and-orchestrating-ribonucleoprotein-assembly-drive-h5-influenza-virus-replication-and-pathogenicity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/dual-roles-of-usp39-in-stabilizing-pb2-and-orchestrating-ribonucleoprotein-assembly-drive-h5-influenza-virus-replication-and-pathogenicity","title":{"rendered":"Dual roles of USP39 in stabilizing PB2 and orchestrating ribonucleoprotein assembly drive H5 influenza virus replication and pathogenicity"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/dual-roles-of-usp39-in-stabilizing-pb2-and-orchestrating-ribonucleoprotein-assembly-drive-h5-influenza-virus-replication-and-pathogenicity2.jpg\"><\/a><\/p>\n<p>Yang et al. identify USP39 as a deubiquitinase hijacked by H5 AIV. USP39 catalytically deubiquitinates PB2 to prevent its degradation and maintain polymerase activity. Meanwhile, it promotes PB2-PB1 association for RNP assembly. The dual-function mechanism facilitates viral replication, enhances pathogenicity, and represents a promising anti-H5 therapeutic target.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yang et al. identify USP39 as a deubiquitinase hijacked by H5 AIV. USP39 catalytically deubiquitinates PB2 to prevent its degradation and maintain polymerase activity. Meanwhile, it promotes PB2-PB1 association for RNP assembly. The dual-function mechanism facilitates viral replication, enhances pathogenicity, and represents a promising anti-H5 therapeutic target.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233484","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233484","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233484"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233484\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233484"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233484"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}