{"id":233429,"date":"2026-03-16T22:18:23","date_gmt":"2026-03-17T03:18:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/compound-amino-acid-synergizes-ceftazidime-avibactam-to-eradicate-extracellular-and-facultative-intracellular-mdr-pathogens"},"modified":"2026-03-16T22:18:23","modified_gmt":"2026-03-17T03:18:23","slug":"compound-amino-acid-synergizes-ceftazidime-avibactam-to-eradicate-extracellular-and-facultative-intracellular-mdr-pathogens","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/compound-amino-acid-synergizes-ceftazidime-avibactam-to-eradicate-extracellular-and-facultative-intracellular-mdr-pathogens","title":{"rendered":"Compound amino acid synergizes ceftazidime-avibactam to eradicate extracellular and facultative intracellular MDR pathogens"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/compound-amino-acid-synergizes-ceftazidime-avibactam-to-eradicate-extracellular-and-facultative-intracellular-mdr-pathogens.jpg\"><\/a><\/p>\n<p>This study demonstrates that the FDA-approved drug 18AA potently resensitizes multidrug-resistant pathogens to ceftazidime-avibactam. It achieves this by activating two bacterial pathways, the inosine-CusS\/R-CusC axis and the proton motive force, to promote antibiotic influx, offering a readily translatable strategy against formidable infections.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study demonstrates that the FDA-approved drug 18AA potently resensitizes multidrug-resistant pathogens to ceftazidime-avibactam. It achieves this by activating two bacterial pathways, the inosine-CusS\/R-CusC axis and the proton motive force, to promote antibiotic influx, offering a readily translatable strategy against formidable infections.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233429","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233429"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233429\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}