{"id":233389,"date":"2026-03-16T10:12:28","date_gmt":"2026-03-16T15:12:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/ty2-is-protective-in-a-rat-model-of-mi-and-in-a-model-of-cecal-ligation-and-puncture-induced-sepsis"},"modified":"2026-03-16T10:12:28","modified_gmt":"2026-03-16T15:12:28","slug":"ty2-is-protective-in-a-rat-model-of-mi-and-in-a-model-of-cecal-ligation-and-puncture-induced-sepsis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/ty2-is-protective-in-a-rat-model-of-mi-and-in-a-model-of-cecal-ligation-and-puncture-induced-sepsis","title":{"rendered":"TY2 is protective in a rat model of MI and in a model of cecal ligation and puncture\u2013induced sepsis"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ty2-is-protective-in-a-rat-model-of-mi-and-in-a-model-of-cecal-ligation-and-puncture-induced-sepsis.jpg\"><\/a><\/p>\n<p>This Research Letter offers a creative approach to sepsis based on a naturally occurring efferocytosis-enhancing RNA<\/p>\n<p>Small noncoding RNA TY2 enhances efferocytosis and improves outcomes in a mouse model of sepsis by Alessandra Ciullo &amp; team: <a href=\"https:\/\/doi.org\/10.1172\/jci.insight\">https:\/\/doi.org\/10.1172\/jci.insight<\/a>.<\/p>\n<p>The image shows exposure to TY2 increases <i>E. coli<\/i> clearance by bone-marrow derived macrophages as indicated by fluorophore as a reporter of efferocytosis (green).<\/p>\n<hr>\n<p>Address correspondence to: Alessandra Ciullo, Smidt Heart Institute, Cedars-Sinai Medical Center, 8,700 Beverly Blvd., Los Angeles, California 90,048, USA. Email: <a href=\"mailto:alessandra.ciullo@cshs.org\">alessandra.ciullo@cshs.org<\/a>.<\/p>\n<p>Find articles by Ciullo, A. in: <a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=search&db=pubmed&term=Ciullo+A[au>&dispmax=50\"]PubMed<\/a> | <a target=\"_blank\" href=\"https:\/\/scholar.google.com\/scholar?q=%22author%3AA+Ciullo%22\">Google Scholar<\/a><\/p>\n<p>Smidt heart institute, cedars-sinai medical center, los angeles, california, USA.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/03\/ty2-is-protective-in-a-rat-model-of-mi-and-in-a-model-of-cecal-ligation-and-puncture-induced-sepsis\">Continue reading \u201cTY2 is protective in a rat model of MI and in a model of cecal ligation and puncture\u2013induced sepsis\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This Research Letter offers a creative approach to sepsis based on a naturally occurring efferocytosis-enhancing RNA Small noncoding RNA TY2 enhances efferocytosis and improves outcomes in a mouse model of sepsis by Alessandra Ciullo &amp; team: https:\/\/doi.org\/10.1172\/jci.insight. The image shows exposure to TY2 increases E. coli clearance by bone-marrow derived macrophages as indicated by fluorophore [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233389","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233389"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233389\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}