{"id":233373,"date":"2026-03-16T02:05:24","date_gmt":"2026-03-16T07:05:24","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/c9orf72-hexanucleotide-repeat-rna-drives-transcriptional-dysregulation-through-genome-wide-dna-rna-hybrid-g-quadruplexes"},"modified":"2026-03-16T02:05:24","modified_gmt":"2026-03-16T07:05:24","slug":"c9orf72-hexanucleotide-repeat-rna-drives-transcriptional-dysregulation-through-genome-wide-dna-rna-hybrid-g-quadruplexes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/c9orf72-hexanucleotide-repeat-rna-drives-transcriptional-dysregulation-through-genome-wide-dna-rna-hybrid-g-quadruplexes","title":{"rendered":"C9orf72 hexanucleotide repeat RNA drives transcriptional dysregulation through genome-wide DNA: RNA hybrid G-quadruplexes"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/c9orf72-hexanucleotide-repeat-rna-drives-transcriptional-dysregulation-through-genome-wide-dna-rna-hybrid-g-quadruplexes2.jpg\"><\/a><\/p>\n<p>Transcriptional dysregulation hexanucleotide repeats in ALS<\/p>\n<p>Repeat hexanucleotide RNAs in <i>C9orf72<\/i> are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia disease pathogenesis but the mechanisms of action remain incompletely understood.<\/p>\n<p>The researchers demonstrate that expanded <i>C9orf72<\/i> G4C2 repeat RNAs bind gene promoters across the genome and form DNA: RNA hybrid G-quadruplexes (HQs) structures with DNA.<\/p>\n<p>These structures obstruct RNA polymerase II and transcription factors, repress gene expression, and heighten neuronal vulnerability, providing mechanistic insights into neurodegeneration in ALS and FTD. sciencenewshighlights ScienceMission <a href=\"https:\/\/sciencemission.com\/hexanucleotide-repeat\">https:\/\/sciencemission.com\/hexanucleotide-repeat<\/a><\/p>\n<hr>\n<p>Liu et al. demonstrate that expanded <i>C9orf72<\/i> G4C2 repeat RNAs bind gene promoters across the genome and form HQ structures with DNA. These structures obstruct key transcription machinery, repress gene expression, and heighten neuronal vulnerability, providing mechanistic insights into neurodegeneration in ALS and FTD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Transcriptional dysregulation hexanucleotide repeats in ALS Repeat hexanucleotide RNAs in C9orf72 are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia disease pathogenesis but the mechanisms of action remain incompletely understood. The researchers demonstrate that expanded C9orf72 G4C2 repeat RNAs bind gene promoters across the genome and form DNA: RNA hybrid G-quadruplexes (HQs) structures with [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-233373","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233373"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233373\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}