{"id":233365,"date":"2026-03-15T22:15:34","date_gmt":"2026-03-16T03:15:34","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/adenosine-signaling-driven-by-the-gut-microbiota-underlies-chronic-alcohol-induced-anesthetic-resistance"},"modified":"2026-03-15T22:15:34","modified_gmt":"2026-03-16T03:15:34","slug":"adenosine-signaling-driven-by-the-gut-microbiota-underlies-chronic-alcohol-induced-anesthetic-resistance","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/adenosine-signaling-driven-by-the-gut-microbiota-underlies-chronic-alcohol-induced-anesthetic-resistance","title":{"rendered":"Adenosine signaling driven by the gut microbiota underlies chronic alcohol-induced anesthetic resistance"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/adenosine-signaling-driven-by-the-gut-microbiota-underlies-chronic-alcohol-induced-anesthetic-resistance.jpg\"><\/a><\/p>\n<p>Wang et al. demonstrate that long-term alcohol consumption diminishes anesthetic sensitivity via a gut-microbiome-brain pathway. Their findings indicate that alcohol-induced dysbiosis elevates the metabolite adenosine, which subsequently downregulates brain GABAA receptors, thereby compromising anesthetic effectiveness.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wang et al. demonstrate that long-term alcohol consumption diminishes anesthetic sensitivity via a gut-microbiome-brain pathway. Their findings indicate that alcohol-induced dysbiosis elevates the metabolite adenosine, which subsequently downregulates brain GABAA receptors, thereby compromising anesthetic effectiveness.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-233365","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233365"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233365\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}