{"id":233274,"date":"2026-03-13T22:21:13","date_gmt":"2026-03-14T03:21:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/a-gain-of-function-retsat-variant-from-high-altitude-adaptation-promotes-myelination-via-a-neuronal-dihydroretinoic-acid-rxr-%ce%b3-pathway"},"modified":"2026-03-13T22:21:13","modified_gmt":"2026-03-14T03:21:13","slug":"a-gain-of-function-retsat-variant-from-high-altitude-adaptation-promotes-myelination-via-a-neuronal-dihydroretinoic-acid-rxr-%ce%b3-pathway","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/a-gain-of-function-retsat-variant-from-high-altitude-adaptation-promotes-myelination-via-a-neuronal-dihydroretinoic-acid-rxr-%ce%b3-pathway","title":{"rendered":"A gain-of-function Retsat variant from high-altitude adaptation promotes myelination via a neuronal dihydroretinoic acid-RXR-\u03b3 pathway"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-gain-of-function-retsat-variant-from-high-altitude-adaptation-promotes-myelination-via-a-neuronal-dihydroretinoic-acid-rxr-ceb3-pathway2.jpg\"><\/a><\/p>\n<p>High-altitude survival gene in mammals may help reverse nerve damage from conditions like multiple sclerosis.<\/p>\n<p>Neuron.<\/p>\n<hr>\n<p>Li et al. report that a gain-of-function <i>Retsat<\/i> variant, associated with high-altitude adaptation, promotes myelination by boosting neuronal synthesis of the signaling metabolite ATDRA. This molecule activates RXR-\u03b3 in oligodendrocyte progenitors. Administration of the prodrug ATDR promotes remyelination in models of myelin disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>High-altitude survival gene in mammals may help reverse nerve damage from conditions like multiple sclerosis. Neuron. Li et al. report that a gain-of-function Retsat variant, associated with high-altitude adaptation, promotes myelination by boosting neuronal synthesis of the signaling metabolite ATDRA. This molecule activates RXR-\u03b3 in oligodendrocyte progenitors. Administration of the prodrug ATDR promotes remyelination in [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-233274","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233274"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233274\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}