{"id":233246,"date":"2026-03-13T11:13:18","date_gmt":"2026-03-13T16:13:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/the-transcriptional-regulator-brd4-is-an-emerging-target-for-cancer-and-other-diseases-in-adults-and-children-however-its-role-in-development-is-not-well-understood"},"modified":"2026-03-13T11:13:18","modified_gmt":"2026-03-13T16:13:18","slug":"the-transcriptional-regulator-brd4-is-an-emerging-target-for-cancer-and-other-diseases-in-adults-and-children-however-its-role-in-development-is-not-well-understood","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/the-transcriptional-regulator-brd4-is-an-emerging-target-for-cancer-and-other-diseases-in-adults-and-children-however-its-role-in-development-is-not-well-understood","title":{"rendered":"The transcriptional regulator BRD4 is an emerging target for cancer and other diseases in adults and children; however, its role in development is not well understood"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-transcriptional-regulator-brd4-is-an-emerging-target-for-cancer-and-other-diseases-in-adults-and-children-however-its-role-in-development-is-not-well-understood.jpg\"><\/a><\/p>\n<p>David B. Frank &amp; team now report BRD4 regulates gene expression and cell differentiation of lung endodermal progenitors into epithelial cells of the lung airways:<\/p>\n<p>The figure shows mutant lungs exhibit fewer and dilated airways with diminished SOX2 expression in distal airways in addition to the formation of cystic distal airway structures.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Department of Pediatrics, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, and.<\/p>\n<p><sup>2<\/sup>CHOP Cardiovascular Institute, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<\/p>\n<p><sup>3<\/sup>Penn Cardiovascular Institute.<\/p>\n<p><sup>4<\/sup>Penn-CHOP Lung Biology Institute, and.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/03\/the-transcriptional-regulator-brd4-is-an-emerging-target-for-cancer-and-other-diseases-in-adults-and-children-however-its-role-in-development-is-not-well-understood\">Continue reading \u201cThe transcriptional regulator BRD4 is an emerging target for cancer and other diseases in adults and children; however, its role in development is not well understood\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>David B. Frank &amp; team now report BRD4 regulates gene expression and cell differentiation of lung endodermal progenitors into epithelial cells of the lung airways: The figure shows mutant lungs exhibit fewer and dilated airways with diminished SOX2 expression in distal airways in addition to the formation of cystic distal airway structures. 1Department of Pediatrics, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233246","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233246"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233246\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233246"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233246"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}