{"id":233197,"date":"2026-03-12T23:41:46","date_gmt":"2026-03-13T04:41:46","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/macrophage-anti-bacterial-activity-is-controlled-by-adenylate-kinase-4-mediated-mitochondrial-dna-synthesis"},"modified":"2026-03-12T23:41:46","modified_gmt":"2026-03-13T04:41:46","slug":"macrophage-anti-bacterial-activity-is-controlled-by-adenylate-kinase-4-mediated-mitochondrial-dna-synthesis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/macrophage-anti-bacterial-activity-is-controlled-by-adenylate-kinase-4-mediated-mitochondrial-dna-synthesis","title":{"rendered":"Macrophage anti-bacterial activity is controlled by adenylate kinase 4\u2013mediated mitochondrial DNA synthesis"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/macrophage-anti-bacterial-activity-is-controlled-by-adenylate-kinase-4-mediated-mitochondrial-dna-synthesis.gif\"><\/a><\/p>\n<p>New from Wei-Yao Chin, Shi-Chuen Miaw et al. (\u570b\u7acb\u81fa\u7063\u5927\u5b78 National Taiwan University): macrophage Ak4 is vital for defense against bacteria. Ak4 fuels mtDNA synthesis \u27a1\ufe0f boosts mtROS production \u27a1\ufe0f kills pathogens. Loss of Ak4 leads to severe susceptibility.<\/p>\n<hr>\n<p>Chin et al. discovered that macrophage-specific Ak4 regulates mtDNA synthesis, through which it controls mitochondrial biogenesis and mtROS levels and, sub.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New from Wei-Yao Chin, Shi-Chuen Miaw et al. (\u570b\u7acb\u81fa\u7063\u5927\u5b78 National Taiwan University): macrophage Ak4 is vital for defense against bacteria. Ak4 fuels mtDNA synthesis \u27a1\ufe0f boosts mtROS production \u27a1\ufe0f kills pathogens. Loss of Ak4 leads to severe susceptibility. Chin et al. discovered that macrophage-specific Ak4 regulates mtDNA synthesis, through which it controls mitochondrial biogenesis and [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233197","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233197"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233197\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}