{"id":233196,"date":"2026-03-12T23:41:05","date_gmt":"2026-03-13T04:41:05","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/defects-in-intron-recycling-suppress-the-antiviral-response-via-a-mechanism-of-intronic-endogenous-dsrna"},"modified":"2026-03-12T23:41:05","modified_gmt":"2026-03-13T04:41:05","slug":"defects-in-intron-recycling-suppress-the-antiviral-response-via-a-mechanism-of-intronic-endogenous-dsrna","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/defects-in-intron-recycling-suppress-the-antiviral-response-via-a-mechanism-of-intronic-endogenous-dsrna","title":{"rendered":"Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/defects-in-intron-recycling-suppress-the-antiviral-response-via-a-mechanism-of-intronic-endogenous-dsrna.gif\"><\/a><\/p>\n<p>New work from Chaorui Duan, William Fairbrother et al. (Brown University) reveals how intronic Alu repeats and RNA metabolism shape endogenous dsRNA levels and cell-intrinsic immunity.<\/p>\n<p>InnateImmunity Inflammation<\/p>\n<hr>\n<p>Defective intron recycling leads to the accumulation of intron-derived double-stranded RNA in the cytoplasm, which suppresses PKR and RNase L activation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New work from Chaorui Duan, William Fairbrother et al. (Brown University) reveals how intronic Alu repeats and RNA metabolism shape endogenous dsRNA levels and cell-intrinsic immunity. InnateImmunity Inflammation Defective intron recycling leads to the accumulation of intron-derived double-stranded RNA in the cytoplasm, which suppresses PKR and RNase L activation.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-233196","post","type-post","status-publish","format-standard","hentry","category-sustainability"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233196"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233196\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}