{"id":233187,"date":"2026-03-12T23:25:12","date_gmt":"2026-03-13T04:25:12","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/pluripotent-stem-based-screening-uncovers-sildenafil-as-a-mitochondrial-disease-therapy"},"modified":"2026-03-12T23:25:12","modified_gmt":"2026-03-13T04:25:12","slug":"pluripotent-stem-based-screening-uncovers-sildenafil-as-a-mitochondrial-disease-therapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/pluripotent-stem-based-screening-uncovers-sildenafil-as-a-mitochondrial-disease-therapy","title":{"rendered":"Pluripotent stem-based screening uncovers sildenafil as a mitochondrial disease therapy"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/pluripotent-stem-based-screening-uncovers-sildenafil-as-a-mitochondrial-disease-therapy2.jpg\"><\/a><\/p>\n<p>Now online! Leigh syndrome is a severe and untreatable mitochondrial disease. Using patient-derived models in 2D and 3D, Zink and colleagues identify the PDE5 inhibitor sildenafil as a repurposable drug candidate, leading to lifespan extension in mammalian models and clinical improvement in six individuals with Leigh syndrome.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Now online! Leigh syndrome is a severe and untreatable mitochondrial disease. Using patient-derived models in 2D and 3D, Zink and colleagues identify the PDE5 inhibitor sildenafil as a repurposable drug candidate, leading to lifespan extension in mammalian models and clinical improvement in six individuals with Leigh syndrome.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233187","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233187","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233187"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233187\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}