{"id":233040,"date":"2026-03-11T03:42:18","date_gmt":"2026-03-11T08:42:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/performance-characteristics-of-genome-sequencing-based-chip-calling-and-impact-on-epidemiologic-associations"},"modified":"2026-03-11T03:42:18","modified_gmt":"2026-03-11T08:42:18","slug":"performance-characteristics-of-genome-sequencing-based-chip-calling-and-impact-on-epidemiologic-associations","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/performance-characteristics-of-genome-sequencing-based-chip-calling-and-impact-on-epidemiologic-associations","title":{"rendered":"Performance characteristics of genome-sequencing\u2013based CHIP calling and impact on epidemiologic associations"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/performance-characteristics-of-genome-sequencing-based-chip-calling-and-impact-on-epidemiologic-associations2.jpg\"><\/a><\/p>\n<p>Do we need better ways to detect clonal hematopoiesis of indeterminate potential (CHIP)?<\/p>\n<p>In this Research Letter, Alexander G. Bick &amp; team find epidemiology studies underestimate the strength of the association between clonal hematopoiesis and disease due to false negatives from shallow, whole-genome versus deep targeted sequencing.<\/p>\n<hr>\n<p>Address correspondence to: Alexander Bick, 2,200 Pierce Ave., 550 RRB, Nashville, Tennessee, 37,232, USA. Email: <a href=\"mailto:alexander.bick@vumc.org\">alexander.bick@vumc.org<\/a>.<\/p>\n<p>Find articles by Corty, R. in: <a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=search&db=pubmed&term=Corty+R[au>&dispmax=50\"]PubMed<\/a> | <a target=\"_blank\" href=\"https:\/\/scholar.google.com\/scholar?q=%22author%3AR+Corty%22\">Google Scholar<\/a><\/p>\n<p><sup>1<\/sup>Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Do we need better ways to detect clonal hematopoiesis of indeterminate potential (CHIP)? In this Research Letter, Alexander G. Bick &amp; team find epidemiology studies underestimate the strength of the association between clonal hematopoiesis and disease due to false negatives from shallow, whole-genome versus deep targeted sequencing. Address correspondence to: Alexander Bick, 2,200 Pierce Ave., [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523],"tags":[],"class_list":["post-233040","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233040"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233040\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}