{"id":232949,"date":"2026-03-10T10:15:25","date_gmt":"2026-03-10T15:15:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/hepatocyte-plagl2-deficiency-alleviates-mash-through-myd88-licensed-inactivation-of-inflammasome"},"modified":"2026-03-10T10:15:25","modified_gmt":"2026-03-10T15:15:25","slug":"hepatocyte-plagl2-deficiency-alleviates-mash-through-myd88-licensed-inactivation-of-inflammasome","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/hepatocyte-plagl2-deficiency-alleviates-mash-through-myd88-licensed-inactivation-of-inflammasome","title":{"rendered":"Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/hepatocyte-plagl2-deficiency-alleviates-mash-through-myd88-licensed-inactivation-of-inflammasome2.jpg\"><\/a><\/p>\n<p>Duan et al. systematically delineate the spatiotemporal dynamics and key regulators of pyroptosis during MASLD progression. Hepatocyte-specific <i>Plagl2<\/i> deletion alleviates MASH by suppressing MYD88-mediated inflammasome activation and restoring metabolic homeostasis. Pyroptosis-driven IL-1\u03b2 release promotes macrophage differentiation into a phagocytosis-enhanced, JAK\/STAT-activated, NASH-associated phenotype.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Duan et al. systematically delineate the spatiotemporal dynamics and key regulators of pyroptosis during MASLD progression. Hepatocyte-specific Plagl2 deletion alleviates MASH by suppressing MYD88-mediated inflammasome activation and restoring metabolic homeostasis. Pyroptosis-driven IL-1\u03b2 release promotes macrophage differentiation into a phagocytosis-enhanced, JAK\/STAT-activated, NASH-associated phenotype.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-232949","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232949"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232949\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}