{"id":232793,"date":"2026-03-07T22:33:38","date_gmt":"2026-03-08T04:33:38","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/a-crispr-based-mitochondrial-gene-therapy-tool-derived-by-engineering-guide-rnas"},"modified":"2026-03-07T22:33:38","modified_gmt":"2026-03-08T04:33:38","slug":"a-crispr-based-mitochondrial-gene-therapy-tool-derived-by-engineering-guide-rnas","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/a-crispr-based-mitochondrial-gene-therapy-tool-derived-by-engineering-guide-rnas","title":{"rendered":"A CRISPR-based mitochondrial gene therapy tool derived by engineering guide RNAs"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-crispr-based-mitochondrial-gene-therapy-tool-derived-by-engineering-guide-rnas2.jpg\"><\/a><\/p>\n<p>Wang et al. systematically analyzed mitochondria-localized lncRNAs to reveal that RBP-motif recognition drives RNA mitochondrial translocation, leading to the engineering of an RNA mitochondrial targeting sequence (RMTS). Fusing RMTS with sgRNA promotes sgRNA mitochondrial entry, establishing a CRISPR-based mitochondrial DNA editing system that ameliorates heteroplasmic mtDNA mutation diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wang et al. systematically analyzed mitochondria-localized lncRNAs to reveal that RBP-motif recognition drives RNA mitochondrial translocation, leading to the engineering of an RNA mitochondrial targeting sequence (RMTS). Fusing RMTS with sgRNA promotes sgRNA mitochondrial entry, establishing a CRISPR-based mitochondrial DNA editing system that ameliorates heteroplasmic mtDNA mutation diseases.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,38,412],"tags":[],"class_list":["post-232793","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-engineering","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232793"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232793\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}