{"id":232759,"date":"2026-03-07T11:06:15","date_gmt":"2026-03-07T17:06:15","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/the-immune-cell-atlas-of-longevity-molecular-tag-identification-of-principal-immune-cell-subsets-and-their-underlying-molecular-regulatory-mechanisms"},"modified":"2026-03-07T11:06:15","modified_gmt":"2026-03-07T17:06:15","slug":"the-immune-cell-atlas-of-longevity-molecular-tag-identification-of-principal-immune-cell-subsets-and-their-underlying-molecular-regulatory-mechanisms","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/the-immune-cell-atlas-of-longevity-molecular-tag-identification-of-principal-immune-cell-subsets-and-their-underlying-molecular-regulatory-mechanisms","title":{"rendered":"The Immune Cell Atlas of \u201cLongevity Molecular Tag\u201d: Identification of Principal Immune Cell Subsets and Their Underlying Molecular Regulatory Mechanisms"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-immune-cell-atlas-of-longevity-molecular-tag-identification-of-principal-immune-cell-subsets-and-their-underlying-molecular-regulatory-mechanisms2.jpg\"><\/a><\/p>\n<p>Immunosenescence represents a critical aspect of the aging process. Centenarians, serving as a nature model of \u201chealthy aging,\u201d demonstrate a distinctive immune \u201ccompensatory adaptation\u201d mechanism that contributes to the maintenance of immune homeostasis. However, the specific immune cell subsets involved and the molecular mechanisms underlying these phenotypic traits remain incompletely understood. In this study, we integrated single-cell RNA sequencing data spanning the entire lifespan of East Asian populations with bulk transcriptomic data from a centenarian cohort in Guangxi. Utilizing the Scissor algorithm, we identified immune cell subpopulations positively (Scissor<sup>+<\/sup>) and negatively (Scissor<sup>\u2212<\/sup>) associated with longevity phenotypes, thereby constructing an immune cell atlas of \u201cLongevity Molecular Tag.\u201d Our findings indicate that Scissor<sup>+<\/sup> cells predominantly comprise natural killer (NK) cells, CD8<sup>+<\/sup> T cells, and \u03b3\u03b4 T cells, characterized by enhanced cytotoxic and immunomodulatory functions. Conversely, Scissor<sup>\u2212<\/sup> cells mainly include CD4<sup>+<\/sup> T cells, B cells, and dendritic cells (DCs), which are linked to inflammatory signaling pathways and Th17\/Th1 differentiation. Trajectory analysis elucidated the differentiation pathways of NK, CD8<sup>+<\/sup> T cells, CD4<sup>+<\/sup> T cells, and B cells. Differentially expressed genes were enriched in pathways such as NF-\u03baB signaling, T cell receptor signaling, and NK cell cytotoxicity. Furthermore, co-localization analysis revealed five eQTL-colocalized events (rs3793537\u2013GLIPR2\/CD72\/TLN1 and rs8019902\u2013TRDV2\/TRDC) associated with longevity. Collectively, these results suggest that centenarians achieve immune equilibrium by remodeling cytotoxic immune lineages and finely tuning inflammatory responses, thereby promoting health span and longevity. This study offers novel insights into potential strategies for modulating immunosenescence.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Immunosenescence represents a critical aspect of the aging process. Centenarians, serving as a nature model of \u201chealthy aging,\u201d demonstrate a distinctive immune \u201ccompensatory adaptation\u201d mechanism that contributes to the maintenance of immune homeostasis. However, the specific immune cell subsets involved and the molecular mechanisms underlying these phenotypic traits remain incompletely understood. In this study, we [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41,269],"tags":[],"class_list":["post-232759","post","type-post","status-publish","format-standard","hentry","category-information-science","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232759"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232759\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}