{"id":232712,"date":"2026-03-06T22:08:45","date_gmt":"2026-03-07T04:08:45","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/continuous-preclinical-activity-reconstruction-in-177lu-based-radiopharmaceutical-therapy-using-a-sparse-uncollimated-%ce%b3-sensor-network"},"modified":"2026-03-06T22:08:45","modified_gmt":"2026-03-07T04:08:45","slug":"continuous-preclinical-activity-reconstruction-in-177lu-based-radiopharmaceutical-therapy-using-a-sparse-uncollimated-%ce%b3-sensor-network","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/continuous-preclinical-activity-reconstruction-in-177lu-based-radiopharmaceutical-therapy-using-a-sparse-uncollimated-%ce%b3-sensor-network","title":{"rendered":"Continuous, Preclinical Activity Reconstruction in 177Lu-based Radiopharmaceutical Therapy Using a Sparse Uncollimated \u03b3-Sensor Network"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/continuous-preclinical-activity-reconstruction-in-177lu-based-radiopharmaceutical-therapy-using-a-sparse-uncollimated-ceb3-sensor-network2.jpg\"><\/a><\/p>\n<p>This RedJournal article presents a first step towards continuous dosimetry in targeted radiopharmaceutical therapy by developing a <i>sparse<\/i> sensor system to reconstruct continuous time-activity curves in preclinical 177Lu-based therapies, demonstrating high accuracy with short scan times.<\/p>\n<hr>\n<p>177Lu-based radiopharmaceutical therapy (RPT) has shown increasing promise in the treatment of neuroendocrine and metastatic prostate cancer. Delivering optimal radiation dose to tumors while minimizing dose to organs-at-risk (OAR) remains an unmet need due to significant patient-to-patient heterogeneity in treatment response, necessitating multiple snapshots of the <i>in vivo<\/i> activity distribution. Towards this goal, here we present a high temporal-resolution activity reconstruction method demonstrated on preclinical prostate cancer models.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This RedJournal article presents a first step towards continuous dosimetry in targeted radiopharmaceutical therapy by developing a sparse sensor system to reconstruct continuous time-activity curves in preclinical 177Lu-based therapies, demonstrating high accuracy with short scan times. 177Lu-based radiopharmaceutical therapy (RPT) has shown increasing promise in the treatment of neuroendocrine and metastatic prostate cancer. Delivering optimal [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1694],"tags":[],"class_list":["post-232712","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-electronics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232712"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232712\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}