{"id":232687,"date":"2026-03-06T10:13:28","date_gmt":"2026-03-06T16:13:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/preventing-hand-foot-syndrome-in-patients-with-cancer-a-systematic-review-and-network-meta-analysis"},"modified":"2026-03-06T10:13:28","modified_gmt":"2026-03-06T16:13:28","slug":"preventing-hand-foot-syndrome-in-patients-with-cancer-a-systematic-review-and-network-meta-analysis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/preventing-hand-foot-syndrome-in-patients-with-cancer-a-systematic-review-and-network-meta-analysis","title":{"rendered":"Preventing Hand-Foot Syndrome in Patients With Cancer: A Systematic Review and Network Meta-Analysis"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/preventing-hand-foot-syndrome-in-patients-with-cancer-a-systematic-review-and-network-meta-analysis2.jpg\"><\/a><\/p>\n<p>In this systematic review and network meta-analysis, diclofenac and silymarin were the most effective preventive strategies for hand-foot syndrome in patients with cancer, with silymarin requiring confirmation in a larger randomized trial.<\/p>\n<p>Diclofenac emerged as the agent with the best overall supporting evidence, informed by both effect estimates and study quality.<\/p>\n<hr>\n<p>Question Which of the prophylactic agents for treating chemotherapy-induced hand-foot syndrome (HFS) is the most effective for preventing clinically significant HFS in patients with cancer?<\/p>\n<p><strong>Findings<\/strong> In this systematic review and network meta-analysis of 17 randomized clinical trials including 2,192 patients, topical diclofenac, silymarin, 400-mg pyridoxine, and celecoxib significantly reduced the incidence of grade 2 or higher HFS compared with placebo; diclofenac and celecoxib were also effective in reducing overall HFS incidence.<\/p>\n<p><strong>Meaning<\/strong> These findings indicate that diclofenac is the prophylactic agent with the best supporting evidence for prevention of HFS in patients with cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this systematic review and network meta-analysis, diclofenac and silymarin were the most effective preventive strategies for hand-foot syndrome in patients with cancer, with silymarin requiring confirmation in a larger randomized trial. Diclofenac emerged as the agent with the best overall supporting evidence, informed by both effect estimates and study quality. Question Which of the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-232687","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232687","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232687"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232687\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232687"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232687"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232687"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}