{"id":232685,"date":"2026-03-06T10:11:35","date_gmt":"2026-03-06T16:11:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/nuclear-pd-l1-regulates-yap-driven-transcription-via-the-pge2-ep4-yap-importin-%ce%b13-axis-in-solid-tumors"},"modified":"2026-03-06T10:11:35","modified_gmt":"2026-03-06T16:11:35","slug":"nuclear-pd-l1-regulates-yap-driven-transcription-via-the-pge2-ep4-yap-importin-%ce%b13-axis-in-solid-tumors","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/nuclear-pd-l1-regulates-yap-driven-transcription-via-the-pge2-ep4-yap-importin-%ce%b13-axis-in-solid-tumors","title":{"rendered":"Nuclear PD-L1 regulates YAP-driven transcription via the PGE2-EP4-YAP-importin \u03b13 axis in solid tumors"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nuclear-pd-l1-regulates-yap-driven-transcription-via-the-pge2-ep4-yap-importin-ceb13-axis-in-solid-tumors2.jpg\"><\/a><\/p>\n<p>Satapathy et al. demonstrate that prostaglandin E2 promotes YAP-dependent nuclear translocation of PD-L1 via importin-\u03b13. In the nucleus, PD-L1 cooperates with YAP-TEAD to enhance transcriptional activity, revealing a noncanonical role for PD-L1 in regulating oncogenic gene expression beyond immune evasion.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Satapathy et al. demonstrate that prostaglandin E2 promotes YAP-dependent nuclear translocation of PD-L1 via importin-\u03b13. In the nucleus, PD-L1 cooperates with YAP-TEAD to enhance transcriptional activity, revealing a noncanonical role for PD-L1 in regulating oncogenic gene expression beyond immune evasion.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-232685","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232685"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232685\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}