{"id":232680,"date":"2026-03-06T10:08:51","date_gmt":"2026-03-06T16:08:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/medaka-a-novel-model-for-analyzing-genome-environment-interactions"},"modified":"2026-03-06T10:08:51","modified_gmt":"2026-03-06T16:08:51","slug":"medaka-a-novel-model-for-analyzing-genome-environment-interactions","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/medaka-a-novel-model-for-analyzing-genome-environment-interactions","title":{"rendered":"Medaka: a novel model for analyzing genome\u2013environment interactions"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/medaka-a-novel-model-for-analyzing-genome-environment-interactions2.jpg\"><\/a><\/p>\n<p>Analyzing genome\u2013 environment interactions using medaka model.<\/p>\n<p>As a temperate fish species, medaka tolerates fluctuating environments (e.g., seasonal changes and different water salinity levels).<\/p>\n<p>Medaka are highly tolerant to inbreeding; a near-isogenic inbred panel named Medaka Inbred Kiyosu-Karlsruhe panel and several wild-derived inbred strains of medaka have been established.<\/p>\n<p>These panels and strains allow the analysis of phenotype\u2013genotype interactions under different environmental conditions and the modeling of human populations.<\/p>\n<p>Advanced epigenomic approaches, including assay for transposase-accessible chromatin using sequencing, highthroughput chromosome conformation capture (Hi-C), and analysis of histone modifications and DNA methylation, extend genomic approaches in our understanding of gene\u2013environment interactions. sciencenewshighlights ScienceMission <a href=\"https:\/\/sciencemission.com\/Medaka\">https:\/\/sciencemission.com\/Medaka<\/a><\/p>\n<hr>\n<p>Medaka is an established vertebrate model system for biological and biomedical research. It possesses unique features that make it particularly suitable for studying genome\u2013environment interactions. Endemic to habitats spanning from 4 to 40\u00b0C and varying salinities, it combines broad ecological adaptability with experimental tractability. Its exceptional tolerance to inbreeding enabled the creation of the Medaka Inbred Kiyosu-Karlsruhe panel\u201480 near-isogenic, fully sequenced lines derived from a single wild population. More than 100 wild-derived, fully sequenced strains, collected throughout East Asia for more than 40 years, show relatively low intra-strain variation (inbreeding coefficient of 0.75) but high inter-strain variability (SNP rates 4%). Advanced quantification methods facilitate genome-wide association studies and quantitative trait locus mapping.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/03\/medaka-a-novel-model-for-analyzing-genome-environment-interactions\">Continue reading \u201cMedaka: a novel model for analyzing genome\u2013environment interactions\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Analyzing genome\u2013 environment interactions using medaka model. As a temperate fish species, medaka tolerates fluctuating environments (e.g., seasonal changes and different water salinity levels). Medaka are highly tolerant to inbreeding; a near-isogenic inbred panel named Medaka Inbred Kiyosu-Karlsruhe panel and several wild-derived inbred strains of medaka have been established. These panels and strains allow the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-232680","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232680","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232680"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232680\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}