{"id":232640,"date":"2026-03-05T22:15:09","date_gmt":"2026-03-06T04:15:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/in-older-adults-aml-often-follows-clonal-hematopoiesis-mutations"},"modified":"2026-03-05T22:15:09","modified_gmt":"2026-03-06T04:15:09","slug":"in-older-adults-aml-often-follows-clonal-hematopoiesis-mutations","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/in-older-adults-aml-often-follows-clonal-hematopoiesis-mutations","title":{"rendered":"In older adults, AML often follows clonal hematopoiesis mutations"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/in-older-adults-aml-often-follows-clonal-hematopoiesis-mutations2.jpg\"><\/a><\/p>\n<p>However, the pathogenic contribution of <i>PTPN11<\/i> mutations has been unclear.<\/p>\n<p>John C. Byrd &amp; team reveal <i>PTPN11<\/i> mutations in AML can be early events in the clonal evolution of disease development and are associated with variably differentiated myeloid cells, based on human and murine studies:<\/p>\n<p>The figure shows lower survival of the Npm1cA<i>\/<i>Ptpn11<\/i><\/i>E76K mouse model.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.<\/p>\n<p><sup>2<\/sup>Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.<\/p>\n<p><sup>3<\/sup>Division of Experimental Hematology and Cancer Biology, Cincinnati Children\u2019s Hospital, Cincinnati, Ohio, USA.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/03\/in-older-adults-aml-often-follows-clonal-hematopoiesis-mutations\">Continue reading \u201cIn older adults, AML often follows clonal hematopoiesis mutations\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>However, the pathogenic contribution of PTPN11 mutations has been unclear. John C. Byrd &amp; team reveal PTPN11 mutations in AML can be early events in the clonal evolution of disease development and are associated with variably differentiated myeloid cells, based on human and murine studies: The figure shows lower survival of the Npm1cA\/Ptpn11E76K mouse model. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,385],"tags":[],"class_list":["post-232640","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-evolution"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232640"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232640\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}