{"id":232614,"date":"2026-03-05T10:09:54","date_gmt":"2026-03-05T16:09:54","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/efficient-amyloid-%ce%b2-degradation-in-alzheimers-disease-using-spytacs"},"modified":"2026-03-05T10:09:54","modified_gmt":"2026-03-05T16:09:54","slug":"efficient-amyloid-%ce%b2-degradation-in-alzheimers-disease-using-spytacs","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/efficient-amyloid-%ce%b2-degradation-in-alzheimers-disease-using-spytacs","title":{"rendered":"Efficient amyloid-\u03b2 degradation in Alzheimer\u2019s disease using SPYTACs"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/efficient-amyloid-ceb2-degradation-in-alzheimers-disease-using-spytacs2.jpg\"><\/a><\/p>\n<p>Now online! SPYTAC is a synthetic peptide-programmed targeted protein degradation platform harnessing LRP1 to drive lysosomal degradation of extracellular amyloid-\u03b2 in the brain and periphery. In 5\u00d7FAD mice, SPYTAC treatment efficiently degrades amyloid-\u03b2, preserves neurons, and improves cognition with reduced neuroinflammation and microhemorrhage when compared with antibody therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Now online! SPYTAC is a synthetic peptide-programmed targeted protein degradation platform harnessing LRP1 to drive lysosomal degradation of extracellular amyloid-\u03b2 in the brain and periphery. In 5\u00d7FAD mice, SPYTAC treatment efficiently degrades amyloid-\u03b2, preserves neurons, and improves cognition with reduced neuroinflammation and microhemorrhage when compared with antibody therapy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-232614","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232614"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232614\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}