{"id":232579,"date":"2026-03-05T02:04:18","date_gmt":"2026-03-05T08:04:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/unbalanced-chromatin-binding-of-polycomb-complexes-drives-neurodevelopmental-disorders"},"modified":"2026-03-05T02:04:18","modified_gmt":"2026-03-05T08:04:18","slug":"unbalanced-chromatin-binding-of-polycomb-complexes-drives-neurodevelopmental-disorders","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/unbalanced-chromatin-binding-of-polycomb-complexes-drives-neurodevelopmental-disorders","title":{"rendered":"Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/unbalanced-chromatin-binding-of-polycomb-complexes-drives-neurodevelopmental-disorders2.jpg\"><\/a><\/p>\n<p>Neurodevelopmental disorders from Polycomb complex missense mutations.<\/p>\n<p>The causes of many neurodevelopmental disorders (NDDs) is yet to be determined.<\/p>\n<p>The researchers report new missense mutations in the Polycomb repressive complex 1 (PRC1) E3 ligases RNF2 and RING1 in individuals with neurodevelopmental disorders.<\/p>\n<p>Functional dissection of a deleterious variant reveals that balanced co-recruitment of Polycomb complexes to chromatin is essential for proper neurogenesis and for normal brain function and behavior. sciencenewshighlights ScienceMission <a href=\"https:\/\/sciencemission.com\/Polycomb-complexes-drives-NDDs\">https:\/\/sciencemission.com\/Polycomb-complexes-drives-NDDs<\/a><\/p>\n<hr>\n<p>Borges, Gonz\u00e1lez-Blanco, Arigela, et al. report new missense mutations in the PRC1 genes RNF2 and RING1 in individuals with neurodevelopmental disorders. Functional dissection of a deleterious variant reveals that balanced co-recruitment of Polycomb complexes to chromatin is essential for proper neurogenesis and for normal brain function and behavior.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neurodevelopmental disorders from Polycomb complex missense mutations. The causes of many neurodevelopmental disorders (NDDs) is yet to be determined. The researchers report new missense mutations in the Polycomb repressive complex 1 (PRC1) E3 ligases RNF2 and RING1 in individuals with neurodevelopmental disorders. Functional dissection of a deleterious variant reveals that balanced co-recruitment of Polycomb complexes [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[412,47],"tags":[],"class_list":["post-232579","post","type-post","status-publish","format-standard","hentry","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232579"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232579\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}