{"id":232561,"date":"2026-03-04T21:05:25","date_gmt":"2026-03-05T03:05:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/one-of-a-kind-microscope-reveals-living-cells-in-unprecedented-detail"},"modified":"2026-03-04T21:05:25","modified_gmt":"2026-03-05T03:05:25","slug":"one-of-a-kind-microscope-reveals-living-cells-in-unprecedented-detail","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/one-of-a-kind-microscope-reveals-living-cells-in-unprecedented-detail","title":{"rendered":"One-of-a-kind microscope reveals living cells in unprecedented detail"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/one-of-a-kind-microscope-reveals-living-cells-in-unprecedented-detail.jpg\"><\/a><\/p>\n<p>Stanford researchers have combined two microscopy techniques to create a one-of-a-kind instrument that can show cell structures interacting in real time at an unprecedented 120-nanometer resolution\u2014the highest achieved without the use of fluorescent labels. This new \u201clabel-free\u201d technology, called Interferometric Image Scanning Microscopy, or iISM, will allow scientists to observe cellular structures in their wider context, including their responses to intrusions, such as pathogens or drugs.<\/p>\n<p>The advance is detailed in <a href=\"https:\/\/www.nature.com\/articles\/s41377-026-02210-y\" target=\"_blank\"><i>Light: Science and Applications<\/i><\/a>. \u201cThis new microscope provides a fantastic new view into the cell, where you can see the tiny structures and machines in the cell moving, changing, and interacting without having to add fluorescence to observe them,\u201d said senior author W.E. Moerner, the Harry S. Mosher Professor of Chemistry in Stanford\u2019s School of Humanities and Sciences.<\/p>\n<p>\u201cIt\u2019s a wonderful look into these complex little cellular boxes that drive our life.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stanford researchers have combined two microscopy techniques to create a one-of-a-kind instrument that can show cell structures interacting in real time at an unprecedented 120-nanometer resolution\u2014the highest achieved without the use of fluorescent labels. This new \u201clabel-free\u201d technology, called Interferometric Image Scanning Microscopy, or iISM, will allow scientists to observe cellular structures in their wider [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-232561","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232561"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232561\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}