{"id":232457,"date":"2026-03-03T10:11:38","date_gmt":"2026-03-03T16:11:38","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/porcine-irf2-suppresses-the-cgas-sting-mediated-antiviral-ifn-signaling-by-competing-irf3-for-binding-to-the-ifn-promoter"},"modified":"2026-03-03T10:11:38","modified_gmt":"2026-03-03T16:11:38","slug":"porcine-irf2-suppresses-the-cgas-sting-mediated-antiviral-ifn-signaling-by-competing-irf3-for-binding-to-the-ifn-promoter","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/porcine-irf2-suppresses-the-cgas-sting-mediated-antiviral-ifn-signaling-by-competing-irf3-for-binding-to-the-ifn-promoter","title":{"rendered":"Porcine IRF2 suppresses the cGAS-STING-mediated antiviral IFN signaling by competing IRF3 for binding to the IFN promoter"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/porcine-irf2-suppresses-the-cgas-sting-mediated-antiviral-ifn-signaling-by-competing-irf3-for-binding-to-the-ifn-promoter2.jpg\"><\/a><\/p>\n<p>Sen Jiang et al. identify porcine IRF2 as a potent inhibitor of innate immune cGAS-STING-IRF3-IFN antiviral signaling pathway via systemic screenings, and they further dissected the mechanism of action by porcine IRF2 for negative regulation. This research unveiled a distinct function of IRF2 and provides justification for intervention of porcine viral diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sen Jiang et al. identify porcine IRF2 as a potent inhibitor of innate immune cGAS-STING-IRF3-IFN antiviral signaling pathway via systemic screenings, and they further dissected the mechanism of action by porcine IRF2 for negative regulation. This research unveiled a distinct function of IRF2 and provides justification for intervention of porcine viral diseases.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-232457","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232457","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232457"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232457\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232457"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232457"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}