{"id":232419,"date":"2026-03-02T21:19:01","date_gmt":"2026-03-03T03:19:01","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/humanization-and-engineering-of-protective-antibodies-targeting-severe-fever-with-thrombocytopenia-syndrome-virus-gn-protein"},"modified":"2026-03-02T21:19:01","modified_gmt":"2026-03-03T03:19:01","slug":"humanization-and-engineering-of-protective-antibodies-targeting-severe-fever-with-thrombocytopenia-syndrome-virus-gn-protein","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/humanization-and-engineering-of-protective-antibodies-targeting-severe-fever-with-thrombocytopenia-syndrome-virus-gn-protein","title":{"rendered":"Humanization and engineering of protective antibodies targeting severe fever with thrombocytopenia syndrome virus Gn protein"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/humanization-and-engineering-of-protective-antibodies-targeting-severe-fever-with-thrombocytopenia-syndrome-virus-gn-protein2.jpg\"><\/a><\/p>\n<p>Ren et al. humanize and structurally optimize a chimeric anti-SFTSV antibody, generating variants with markedly enhanced neutralization potency by strengthening binding to recombinant Gn and intact virions, providing full <i>in vivo<\/i> protection and establishing a generalizable framework for therapeutic antibody engineering.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ren et al. humanize and structurally optimize a chimeric anti-SFTSV antibody, generating variants with markedly enhanced neutralization potency by strengthening binding to recombinant Gn and intact virions, providing full in vivo protection and establishing a generalizable framework for therapeutic antibody engineering.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11],"tags":[],"class_list":["post-232419","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232419"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232419\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}