{"id":232415,"date":"2026-03-02T21:14:01","date_gmt":"2026-03-03T03:14:01","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/genetic-sequencing-has-aided-in-the-discovery-of-novel-mutations-in-inborn-errors-of-immunity-but-their-clinical-relevance-often-remains-unclear"},"modified":"2026-03-02T21:14:01","modified_gmt":"2026-03-03T03:14:01","slug":"genetic-sequencing-has-aided-in-the-discovery-of-novel-mutations-in-inborn-errors-of-immunity-but-their-clinical-relevance-often-remains-unclear","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/genetic-sequencing-has-aided-in-the-discovery-of-novel-mutations-in-inborn-errors-of-immunity-but-their-clinical-relevance-often-remains-unclear","title":{"rendered":"Genetic sequencing has aided in the discovery of novel mutations in inborn errors of immunity, but their clinical relevance often remains unclear"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/genetic-sequencing-has-aided-in-the-discovery-of-novel-mutations-in-inborn-errors-of-immunity-but-their-clinical-relevance-often-remains-unclear2.jpg\"><\/a><\/p>\n<p>In this Research Article, Marcus Altfeld &amp; team identify a TLR8 gene mutation causing immune overactivation and inflammation in two siblings, linking genetic change to immune system dysfunction and disease: Immunology.<\/p>\n<hr>\n<p>\n<sup>14 <\/sup>Hamburg Center for Translational Immunology;<\/p>\n<p><sup>15 <\/sup>German Center for Child and Adolescent Health (DZKJ), partner site Hamburg; and.<\/p>\n<p><sup>16 <\/sup>Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this Research Article, Marcus Altfeld &amp; team identify a TLR8 gene mutation causing immune overactivation and inflammation in two siblings, linking genetic change to immune system dysfunction and disease: Immunology. 14 Hamburg Center for Translational Immunology; 15 German Center for Child and Adolescent Health (DZKJ), partner site Hamburg; and. 16 Institute of Medical Microbiology, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-232415","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232415"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232415\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}