{"id":232406,"date":"2026-03-02T17:07:55","date_gmt":"2026-03-02T23:07:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/mdsgene-systematic-review-of-common-forms-of-dominant-hereditary-spastic-paraplegia-novel-insights"},"modified":"2026-03-02T17:07:55","modified_gmt":"2026-03-02T23:07:55","slug":"mdsgene-systematic-review-of-common-forms-of-dominant-hereditary-spastic-paraplegia-novel-insights","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/mdsgene-systematic-review-of-common-forms-of-dominant-hereditary-spastic-paraplegia-novel-insights","title":{"rendered":"MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mdsgene-systematic-review-of-common-forms-of-dominant-hereditary-spastic-paraplegia-novel-insights2.jpg\"><\/a><\/p>\n<p>Hereditary spastic paraplegia refers to a group of disorders characterized by progressive spasticity of lower extremities. The Genetic Nomenclature Study Group found differing frequency of variant types across 3 HSP genes: <i>ATL1, SPAST<\/i> and REEP1.<\/p>\n<hr>\n<p>The PubMed literature search and articles obtained through additional sources yielded a total of 239 articles for HSP\u2013<i>ATL1<\/i>, of which 70 were eligible, 531 articles for HSP\u2013<i>SPAST<\/i>, for which 187 were eligible, and 334 articles for HSP\u2013<i>REEP1<\/i>, of which 31 were eligible (Fig. <a href=\"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70559#mdc370559-fig-0001\">1<\/a>, Supplementary File_HSP Article Screening Log).<\/p>\n<p>By classifying these articles according to study type, we found that the most common were genetic screening studies (36.3%), family studies (30.4%), followed by, case reports\/series (23.2%), and other\/mixed-type studies (10.0%). While genetic screening studies were the most common study type for HSP\u2013<i>SPAST<\/i> and HSP\u2013<i>REEP1<\/i>, family studies were the most common study type for HSP\u2013<i>ATL1<\/i> (<a class=\"\" href=\"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70559#support-information-section\">Table S2<\/a>).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hereditary spastic paraplegia refers to a group of disorders characterized by progressive spasticity of lower extremities. The Genetic Nomenclature Study Group found differing frequency of variant types across 3 HSP genes: ATL1, SPAST and REEP1. The PubMed literature search and articles obtained through additional sources yielded a total of 239 articles for HSP\u2013ATL1, of which [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[412],"tags":[],"class_list":["post-232406","post","type-post","status-publish","format-standard","hentry","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232406","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232406"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232406\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232406"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}