{"id":232303,"date":"2026-02-28T18:20:13","date_gmt":"2026-03-01T00:20:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/engineered-protein-markers-read-living-brain-gene-activity-in-monkeys-via-blood"},"modified":"2026-02-28T18:20:13","modified_gmt":"2026-03-01T00:20:13","slug":"engineered-protein-markers-read-living-brain-gene-activity-in-monkeys-via-blood","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/engineered-protein-markers-read-living-brain-gene-activity-in-monkeys-via-blood","title":{"rendered":"Engineered protein markers read living brain gene activity in monkeys via blood"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/engineered-protein-markers-read-living-brain-gene-activity-in-monkeys-via-blood.jpg\"><\/a><\/p>\n<p>Gene therapy has been successfully used to treat a number of diseases, including immune deficiencies, hereditary blindness, hemophilia and, recently, Huntington\u2019s disease, a fatal neurological disorder.<\/p>\n<p>An advance <a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627326000036\" target=\"_blank\">reported<\/a> in the journal <i>Neuron<\/i> adds to the technique\u2019s growing track record of evidence supporting the view that it could unlock powerful, personalized therapies: Rice University bioengineer Jerzy Szablowski and collaborators in Vincent Costa\u2019s lab at Emory University found that released markers of activity (RMAs) \u2014 engineered proteins designed to cross the blood-brain barrier and persist in the blood for hours at a time, providing a reliable and noninvasive way to get information about gene expression in the brain \u2014 work just as well in monkeys as they do <a href=\"https:\/\/medicalxpress.com\/news\/2024-01-scientists-blood-track-gene-brain.html\">in mice<\/a>.<\/p>\n<p>On the route from laboratory discovery to lifesaving treatment, large animal model studies are a critical part of the process. Most research never reaches this stage.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gene therapy has been successfully used to treat a number of diseases, including immune deficiencies, hereditary blindness, hemophilia and, recently, Huntington\u2019s disease, a fatal neurological disorder. An advance reported in the journal Neuron adds to the technique\u2019s growing track record of evidence supporting the view that it could unlock powerful, personalized therapies: Rice University bioengineer [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,47],"tags":[],"class_list":["post-232303","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232303"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232303\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232303"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232303"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}