{"id":232294,"date":"2026-02-28T14:15:25","date_gmt":"2026-02-28T20:15:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/distances-and-charges-along-the-orai1-nexus-tm3-interface-control-stim1-binding-and-pore-opening"},"modified":"2026-02-28T14:15:25","modified_gmt":"2026-02-28T20:15:25","slug":"distances-and-charges-along-the-orai1-nexus-tm3-interface-control-stim1-binding-and-pore-opening","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/distances-and-charges-along-the-orai1-nexus-tm3-interface-control-stim1-binding-and-pore-opening","title":{"rendered":"Distances and charges along the Orai1 nexus-TM3 interface control STIM1 binding and pore opening"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/distances-and-charges-along-the-orai1-nexus-tm3-interface-control-stim1-binding-and-pore-opening2.jpg\"><\/a><\/p>\n<p>Calcium influx through CRAC channels requires STIM1 binding to Orai1. Using crosslinking and mutagenesis, S\u00f6llner et al. show that widening the nexus-TM3 interface near the STIM1 coupling site is crucial for channel opening, while hydrophobicity and charges support signal transmission to the pore. Nexus-TM3 dynamics are vital for Orai1 function.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Calcium influx through CRAC channels requires STIM1 binding to Orai1. Using crosslinking and mutagenesis, S\u00f6llner et al. show that widening the nexus-TM3 interface near the STIM1 coupling site is crucial for channel opening, while hydrophobicity and charges support signal transmission to the pore. Nexus-TM3 dynamics are vital for Orai1 function.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-232294","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232294"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232294\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}