{"id":232291,"date":"2026-02-28T14:12:40","date_gmt":"2026-02-28T20:12:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/baseline-fatigue-and-severe-toxic-effects-in-patients-with-cancer-receiving-systemic-therapy"},"modified":"2026-02-28T14:12:40","modified_gmt":"2026-02-28T20:12:40","slug":"baseline-fatigue-and-severe-toxic-effects-in-patients-with-cancer-receiving-systemic-therapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/baseline-fatigue-and-severe-toxic-effects-in-patients-with-cancer-receiving-systemic-therapy","title":{"rendered":"Baseline Fatigue and Severe Toxic Effects in Patients With Cancer Receiving Systemic Therapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/baseline-fatigue-and-severe-toxic-effects-in-patients-with-cancer-receiving-systemic-therapy2.jpg\"><\/a><\/p>\n<p>Among over 7,000 patients with cancer, higher baseline fatigue before systemic therapy was linked to an increased risk of severe, life-threatening, and fatal adverse events.<\/p>\n<hr>\n<p>Question Is baseline patient-reported fatigue associated with subsequent cancer treatment\u2212related adverse events?<\/p>\n<p><strong>Findings<\/strong> In this cohort study and pooled analysis of 7,086 patients from 17 SWOG phase 2 and 3 randomized clinical trials, patients who reported baseline fatigue had a significantly higher risk of severe, life-threatening, and fatal adverse events. In addition, a dose-response pattern was observed, with patients reporting high fatigue vs no fatigue having a nearly 5-fold increased risk of fatal toxic effects.<\/p>\n<p><strong>Meaning<\/strong> Patient fatigue reported before cancer treatment may serve as an early clinical marker of risk for toxic effects and could help guide personalized treatment strategies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Among over 7,000 patients with cancer, higher baseline fatigue before systemic therapy was linked to an increased risk of severe, life-threatening, and fatal adverse events. Question Is baseline patient-reported fatigue associated with subsequent cancer treatment\u2212related adverse events? Findings In this cohort study and pooled analysis of 7,086 patients from 17 SWOG phase 2 and 3 [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-232291","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232291"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232291\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}