{"id":232230,"date":"2026-02-27T13:17:55","date_gmt":"2026-02-27T19:17:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/balancing-il-17-mediated-protection-and-ifn-%ce%b3-driven-pathology-at-mucocutaneous-barriers"},"modified":"2026-02-27T13:17:55","modified_gmt":"2026-02-27T19:17:55","slug":"balancing-il-17-mediated-protection-and-ifn-%ce%b3-driven-pathology-at-mucocutaneous-barriers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/balancing-il-17-mediated-protection-and-ifn-%ce%b3-driven-pathology-at-mucocutaneous-barriers","title":{"rendered":"Balancing IL-17\u2013mediated protection and IFN-\u03b3\u2013driven pathology at mucocutaneous barriers"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/balancing-il-17-mediated-protection-and-ifn-ceb3-driven-pathology-at-mucocutaneous-barriers2.jpg\"><\/a><\/p>\n<p>Controlling mucocutaneous barriers by cytokines.<\/p>\n<p>Impaired IL-17 leads to mucocutaneous bacterial and fungal infections, whereas enhanced IL-17 promotes psoriasis and periodontitis.<\/p>\n<p>Interferon (IFN)-\u03b3 deficiency causes infections by intracellular pathogens, whereas exacerbated mucosal IFN-\u03b3 activity promotes oral candidiasis, even when IL-17 responses are intact.<\/p>\n<p>JAK inhibition in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy remits oral candidiasis and multiorgan autoimmunity.<\/p>\n<p>IFN-\u03b3 drives <i><i>Candida<\/i> auris<\/i> skin infection by impairing the epithelial barrier. Excess IFN-\u03b3, tumor necrosis factor, and types I\/III IFN activities contribute to pathology during bacterial and protozoan skin infections and pulmonary viral, bacterial, mycobacterial, and fungal infections.<\/p>\n<p>Although immune deficiency causes mucosal infection, epithelial disruption by immunopathology represents a novel and underappreciated mechanism of infection susceptibility at barrier sites. sciencenewshighlights ScienceMission <a href=\"https:\/\/sciencemission.com\/Balancing-IL-17\">https:\/\/sciencemission.com\/Balancing-IL-17<\/a><\/p>\n<hr>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/02\/balancing-il-17-mediated-protection-and-ifn-%ce%b3-driven-pathology-at-mucocutaneous-barriers\">Continue reading \u201cBalancing IL-17\u2013mediated protection and IFN-\u03b3\u2013driven pathology at mucocutaneous barriers\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Controlling mucocutaneous barriers by cytokines. Impaired IL-17 leads to mucocutaneous bacterial and fungal infections, whereas enhanced IL-17 promotes psoriasis and periodontitis. Interferon (IFN)-\u03b3 deficiency causes infections by intracellular pathogens, whereas exacerbated mucosal IFN-\u03b3 activity promotes oral candidiasis, even when IL-17 responses are intact. JAK inhibition in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy remits oral candidiasis and multiorgan autoimmunity. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[412],"tags":[],"class_list":["post-232230","post","type-post","status-publish","format-standard","hentry","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232230"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232230\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}