{"id":232169,"date":"2026-02-26T21:17:44","date_gmt":"2026-02-27T03:17:44","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/pde5a-cancer-associated-fibroblasts-enhance-immune-suppression-in-gastric-cancer"},"modified":"2026-02-26T21:17:44","modified_gmt":"2026-02-27T03:17:44","slug":"pde5a-cancer-associated-fibroblasts-enhance-immune-suppression-in-gastric-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/pde5a-cancer-associated-fibroblasts-enhance-immune-suppression-in-gastric-cancer","title":{"rendered":"PDE5A+ cancer-associated fibroblasts enhance immune suppression in gastric cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/pde5a-cancer-associated-fibroblasts-enhance-immune-suppression-in-gastric-cancer.jpg\"><\/a><\/p>\n<p>GUTImage from the paper by Wang et al entitled.<\/p>\n<p>via.<\/p>\n<p><a href=\"https:\/\/bit.ly\/4ae9wtW\">https:\/\/bit.ly\/4ae9wtW<\/a><\/p>\n<p>GastricCancer.<\/p>\n<hr>\n<p>Background Gastric cancer (GC) ranks among the most prevalent lethal tumours globally. Cancer-associated fibroblasts (CAFs) are pivotal in creating an immunosuppressive tumour microenvironment (TME) in GC.<\/p>\n<p>Objective Identifying a critical subpopulation of CAFs in promoting an immunosuppressive TME and enabling immune evasion, which may influence therapeutic effectiveness of immune checkpoint inhibitors (ICIs) for GC.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/02\/pde5a-cancer-associated-fibroblasts-enhance-immune-suppression-in-gastric-cancer\">Continue reading \u201cPDE5A+ cancer-associated fibroblasts enhance immune suppression in gastric cancer\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>GUTImage from the paper by Wang et al entitled. via. https:\/\/bit.ly\/4ae9wtW GastricCancer. Background Gastric cancer (GC) ranks among the most prevalent lethal tumours globally. Cancer-associated fibroblasts (CAFs) are pivotal in creating an immunosuppressive tumour microenvironment (TME) in GC. Objective Identifying a critical subpopulation of CAFs in promoting an immunosuppressive TME and enabling immune evasion, which [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-232169","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232169"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232169\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}