{"id":232111,"date":"2026-02-25T21:12:23","date_gmt":"2026-02-26T03:12:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/lack-of-pck1-in-hepatic-stellate-cells-causes-liver-fibrosis-by-fueling-tricarboxylic-acid-cycle-and-increasing-glycolysis"},"modified":"2026-02-25T21:12:23","modified_gmt":"2026-02-26T03:12:23","slug":"lack-of-pck1-in-hepatic-stellate-cells-causes-liver-fibrosis-by-fueling-tricarboxylic-acid-cycle-and-increasing-glycolysis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/lack-of-pck1-in-hepatic-stellate-cells-causes-liver-fibrosis-by-fueling-tricarboxylic-acid-cycle-and-increasing-glycolysis","title":{"rendered":"Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/lack-of-pck1-in-hepatic-stellate-cells-causes-liver-fibrosis-by-fueling-tricarboxylic-acid-cycle-and-increasing-glycolysis2.jpg\"><\/a><\/p>\n<p>Online now: This study shows that a key metabolic enzyme, PCK1, protects the liver from scarring by keeping fibrogenic cells in a quiescent state. When PCK1 is reduced, these cells undergo metabolic reprogramming characterized by increased glycolysis, become aberrantly activated, and promote liver fibrosis in mice.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Online now: This study shows that a key metabolic enzyme, PCK1, protects the liver from scarring by keeping fibrogenic cells in a quiescent state. When PCK1 is reduced, these cells undergo metabolic reprogramming characterized by increased glycolysis, become aberrantly activated, and promote liver fibrosis in mice.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-232111","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=232111"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/232111\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=232111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=232111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=232111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}