{"id":231997,"date":"2026-02-24T17:04:25","date_gmt":"2026-02-24T23:04:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair"},"modified":"2026-02-24T17:04:25","modified_gmt":"2026-02-24T23:04:25","slug":"fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair","title":{"rendered":"FDA Greenlights Life Biosciences\u2019 Human Study, Setting Up Pivotal Test for Aging Theory from Harvard\u2019s David Sinclair"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair.jpg\"><\/a><\/p>\n<p>\u2026Life Biosciences, a biotech company co-founded by Sinclair, received the FDA\u2019s approval to begin a human trial testing its gene therapy based on the Information Theory of Aging. The gene therapy is designed to rewind the clock and restore the function of dying cells\u2026<\/p>\n<p>\u2026Life Biosciences\u2019 gene therapy has been under development for quite a while. In the 1990s, David Sinclair first contended that the deterioration and loss of epigenetic information\u2014chemical tagging patterns on DNA that regulate which genes are turned on and off\u2014plays an important role in driving aging. Sinclair subsequently dubbed this contention the Information Theory of Aging. Fast forward to the present day, and Life Biosciences has produced a gene therapy that delivers three proteins, which Sinclair\u2019s laboratory helped establish, to reset epigenetic information to a more youthful state.<\/p>\n<p>\u2018It\u2019s extremely exciting,\u2019 Sinclair told Endpoints News. \u2018It\u2019s been over 30 years to get to this point, and we\u2019re about to learn if all of that work is going to come to fruition this year.\u2019<\/p>\n<hr>\n<p>The FDA has greenlighted Life Biosciences\u2019 first human trial testing whether their gene therapy can confer a near-total rejuvenating reset of cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2026Life Biosciences, a biotech company co-founded by Sinclair, received the FDA\u2019s approval to begin a human trial testing its gene therapy based on the Information Theory of Aging. The gene therapy is designed to rewind the clock and restore the function of dying cells\u2026 \u2026Life Biosciences\u2019 gene therapy has been under development for quite a [\u2026]<\/p>\n","protected":false},"author":542,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,412,269],"tags":[],"class_list":["post-231997","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231997","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/542"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231997"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231997\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231997"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}