{"id":231972,"date":"2026-02-23T22:44:46","date_gmt":"2026-02-24T04:44:46","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/nad-sensing-by-parp7-regulates-the-c-ebp%ce%b2-dependent-transcription-program-during-adipogenesis"},"modified":"2026-02-23T22:44:46","modified_gmt":"2026-02-24T04:44:46","slug":"nad-sensing-by-parp7-regulates-the-c-ebp%ce%b2-dependent-transcription-program-during-adipogenesis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/nad-sensing-by-parp7-regulates-the-c-ebp%ce%b2-dependent-transcription-program-during-adipogenesis","title":{"rendered":"NAD+ sensing by PARP7 regulates the C\/EBP\u03b2-dependent transcription program during adipogenesis"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nad-sensing-by-parp7-regulates-the-c-ebpceb2-dependent-transcription-program-during-adipogenesis3.jpg\"><\/a><\/p>\n<p>Stokes et al. demonstrate that PARP7 \u201csenses\u201d the levels of nuclear NAD+ during early adipogenic differentiation via an ADP-ribosylation-ubiquitin-proteasome pathway to regulate C\/EBP\u03b2-dependent proadipogenic gene expression through p300-mediated H3K27 acetylation. Stabilized PARP7 promotes the binding of C\/EBP\u03b2 to chromatin genome-wide, enhancing lipid synthesis and adipogenesis in vivo.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stokes et al. demonstrate that PARP7 \u201csenses\u201d the levels of nuclear NAD+ during early adipogenic differentiation via an ADP-ribosylation-ubiquitin-proteasome pathway to regulate C\/EBP\u03b2-dependent proadipogenic gene expression through p300-mediated H3K27 acetylation. Stabilized PARP7 promotes the binding of C\/EBP\u03b2 to chromatin genome-wide, enhancing lipid synthesis and adipogenesis in vivo.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-231972","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231972"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231972\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231972"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231972"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}