{"id":231971,"date":"2026-02-23T22:43:35","date_gmt":"2026-02-24T04:43:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/a-neuron-subtype-specific-role-of-mek-erk-signaling-in-axon-survival-via-transcriptional-regulation-of-nmnat2"},"modified":"2026-02-23T22:43:35","modified_gmt":"2026-02-24T04:43:35","slug":"a-neuron-subtype-specific-role-of-mek-erk-signaling-in-axon-survival-via-transcriptional-regulation-of-nmnat2","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/a-neuron-subtype-specific-role-of-mek-erk-signaling-in-axon-survival-via-transcriptional-regulation-of-nmnat2","title":{"rendered":"A neuron subtype-specific role of MEK-ERK signaling in axon survival via transcriptional regulation of Nmnat2"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-neuron-subtype-specific-role-of-mek-erk-signaling-in-axon-survival-via-transcriptional-regulation-of-nmnat22.jpg\"><\/a><\/p>\n<p>Yue et al. find the subtype-specific regulation of <i>Nmnat2<\/i> transcription by Raf-MEK-ERK in DRG neurons, while cortical and spinal neurons use a MEK-independent mechanism. This context-dependent axon survival paradigm helps explain differential MEKi vulnerability of PNS and CNS neurons, indicating <i>Nmnat2<\/i> as a potential target to counteract MEKi-induced neuropathy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yue et al. find the subtype-specific regulation of Nmnat2 transcription by Raf-MEK-ERK in DRG neurons, while cortical and spinal neurons use a MEK-independent mechanism. This context-dependent axon survival paradigm helps explain differential MEKi vulnerability of PNS and CNS neurons, indicating Nmnat2 as a potential target to counteract MEKi-induced neuropathy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-231971","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231971","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231971"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231971\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231971"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231971"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231971"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}