{"id":231881,"date":"2026-02-22T21:05:42","date_gmt":"2026-02-23T03:05:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/hrd1-negatively-regulates-autolysosome-formation-by-inhibiting-liquid-liquid-phase-separation-of-snap29"},"modified":"2026-02-22T21:05:42","modified_gmt":"2026-02-23T03:05:42","slug":"hrd1-negatively-regulates-autolysosome-formation-by-inhibiting-liquid-liquid-phase-separation-of-snap29","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/hrd1-negatively-regulates-autolysosome-formation-by-inhibiting-liquid-liquid-phase-separation-of-snap29","title":{"rendered":"HRD1 negatively regulates autolysosome formation by inhibiting liquid-liquid phase separation of SNAP29"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/hrd1-negatively-regulates-autolysosome-formation-by-inhibiting-liquid-liquid-phase-separation-of-snap292.jpg\"><\/a><\/p>\n<p>Qu et al. identify HRD1 as a key negative regulator of autophagosome-lysosome fusion. They demonstrate that HRD1 interacts with the SNARE protein <i>SNAP29<\/i> to suppress its liquid-liquid phase separation. This work establishes the regulation of SNARE complex assembly via phase separation as a critical control mechanism for autophagy progression.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Qu et al. identify HRD1 as a key negative regulator of autophagosome-lysosome fusion. They demonstrate that HRD1 interacts with the SNARE protein SNAP29 to suppress its liquid-liquid phase separation. This work establishes the regulation of SNARE complex assembly via phase separation as a critical control mechanism for autophagy progression.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-231881","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231881"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231881\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}