{"id":231799,"date":"2026-02-21T09:11:46","date_gmt":"2026-02-21T15:11:46","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/sometimes-less-is-more-messier-nanoparticles-may-actually-deliver-drugs-more-effectively-than-tightly-packed-ones"},"modified":"2026-02-21T09:11:46","modified_gmt":"2026-02-21T15:11:46","slug":"sometimes-less-is-more-messier-nanoparticles-may-actually-deliver-drugs-more-effectively-than-tightly-packed-ones","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/sometimes-less-is-more-messier-nanoparticles-may-actually-deliver-drugs-more-effectively-than-tightly-packed-ones","title":{"rendered":"Sometimes less is more: Messier nanoparticles may actually deliver drugs more effectively than tightly packed ones"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/sometimes-less-is-more-messier-nanoparticles-may-actually-deliver-drugs-more-effectively-than-tightly-packed-ones2.jpg\"><\/a><\/p>\n<p>The tiny fatty capsules that deliver COVID-19 mRNA vaccines into billions of arms may work better when they\u2019re a little disorganized. That\u2019s the surprising finding from researchers who developed a new way to examine these drug-delivery vehicles one particle at a time\u2014revealing that cramming in more medicine doesn\u2019t always mean better results.<\/p>\n<p>The research was presented at the <a href=\"https:\/\/www.biophysics.org\/2026meeting\" target=\"_blank\">70th Biophysical Society Annual Meeting<\/a>, held in San Francisco from February 21\u201325, 2026.<\/p>\n<p>Lipid nanoparticles, or LNPs, are microscopic bubbles of fat that can ferry fragile RNA molecules into cells. They were crucial to the success of mRNA vaccines, and scientists are now working to use them to deliver treatments for cancer, genetic diseases, and other conditions. But there\u2019s a problem: only about 1% to 5% of the cargo inside LNPs actually gets released inside cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The tiny fatty capsules that deliver COVID-19 mRNA vaccines into billions of arms may work better when they\u2019re a little disorganized. That\u2019s the surprising finding from researchers who developed a new way to examine these drug-delivery vehicles one particle at a time\u2014revealing that cramming in more medicine doesn\u2019t always mean better results. The research was [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,4],"tags":[],"class_list":["post-231799","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231799","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231799"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231799\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231799"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231799"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}