{"id":231656,"date":"2026-02-19T18:11:36","date_gmt":"2026-02-20T00:11:36","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/dot1l-provides-transcriptional-memory-through-prc1-1-antagonism"},"modified":"2026-02-19T18:11:36","modified_gmt":"2026-02-20T00:11:36","slug":"dot1l-provides-transcriptional-memory-through-prc1-1-antagonism","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/dot1l-provides-transcriptional-memory-through-prc1-1-antagonism","title":{"rendered":"DOT1L provides transcriptional memory through PRC1.1 antagonism"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/dot1l-provides-transcriptional-memory-through-prc1-1-antagonism.jpg\"><\/a><\/p>\n<p>Genetic off switch for cancer <span class=\"wp-smiley emoji emoji-face_with_colon_three\" title=\":3\">face_with_colon_three<\/span> #cancer #cure<\/p>\n<hr>\n<p>Neville, Ferguson <i>et al.<\/i> show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibitors in mixed-lineage leukaemia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genetic off switch for cancer face_with_colon_three #cancer #cure Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibitors in mixed-lineage leukaemia.<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-231656","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231656"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231656\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}