{"id":231644,"date":"2026-02-19T13:19:24","date_gmt":"2026-02-19T19:19:24","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/mettl3-cd98-mediated-glutamate-efflux-in-cafs-drives-cd8-t-cell-exhaustion-and-impedes-neoadjuvant-immunochemotherapy"},"modified":"2026-02-19T13:19:24","modified_gmt":"2026-02-19T19:19:24","slug":"mettl3-cd98-mediated-glutamate-efflux-in-cafs-drives-cd8-t-cell-exhaustion-and-impedes-neoadjuvant-immunochemotherapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/mettl3-cd98-mediated-glutamate-efflux-in-cafs-drives-cd8-t-cell-exhaustion-and-impedes-neoadjuvant-immunochemotherapy","title":{"rendered":"METTL3\/CD98-mediated glutamate efflux in CAFs drives CD8+ T cell exhaustion and impedes neoadjuvant immunochemotherapy"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mettl3-cd98-mediated-glutamate-efflux-in-cafs-drives-cd8-t-cell-exhaustion-and-impedes-neoadjuvant-immunochemotherapy2.jpg\"><\/a><\/p>\n<p>Feng et al. demonstrate that high levels of glutamate are a characteristic of cancer. The <i>METTL3<\/i>\/m6A\/CD98 axis in cancer-associated fibroblasts promotes glutamate secretion, which in turn promotes the exhaustion of CD8+ T cells and inhibits the formation of immune memory. Targeting glutamate can sensitize neoadjuvant immunochemotherapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Feng et al. demonstrate that high levels of glutamate are a characteristic of cancer. The METTL3\/m6A\/CD98 axis in cancer-associated fibroblasts promotes glutamate secretion, which in turn promotes the exhaustion of CD8+ T cells and inhibits the formation of immune memory. Targeting glutamate can sensitize neoadjuvant immunochemotherapy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-231644","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231644","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231644"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231644\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231644"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231644"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231644"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}