{"id":231576,"date":"2026-02-18T14:16:30","date_gmt":"2026-02-18T20:16:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/lipid-droplet-induced-t-cell-death-sustains-autoimmune-tissue-inflammation"},"modified":"2026-02-18T14:16:30","modified_gmt":"2026-02-18T20:16:30","slug":"lipid-droplet-induced-t-cell-death-sustains-autoimmune-tissue-inflammation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/lipid-droplet-induced-t-cell-death-sustains-autoimmune-tissue-inflammation","title":{"rendered":"Lipid droplet-induced T cell death sustains autoimmune tissue inflammation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/lipid-droplet-induced-t-cell-death-sustains-autoimmune-tissue-inflammation2.jpg\"><\/a><\/p>\n<p>Kumar et al. identify a metabolically controlled trait of CD4+ T cells in autoimmune disease. Exposed to fatty acids in rheumatoid joints, they form lipid droplets containing pore-forming gasdermin D and its activator <i>zDHHC5<\/i>. These droplets induce plasma membrane lysis, resulting in the leakage of intracellular contents and tissue inflammation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kumar et al. identify a metabolically controlled trait of CD4+ T cells in autoimmune disease. Exposed to fatty acids in rheumatoid joints, they form lipid droplets containing pore-forming gasdermin D and its activator zDHHC5. These droplets induce plasma membrane lysis, resulting in the leakage of intracellular contents and tissue inflammation.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-231576","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231576"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231576\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}