{"id":231557,"date":"2026-02-18T05:05:23","date_gmt":"2026-02-18T11:05:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/germline-mutations-in-dicer1-and-dgcr8-can-lead-to-a-range-of-thyroid-conditions"},"modified":"2026-02-18T05:05:23","modified_gmt":"2026-02-18T11:05:23","slug":"germline-mutations-in-dicer1-and-dgcr8-can-lead-to-a-range-of-thyroid-conditions","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/germline-mutations-in-dicer1-and-dgcr8-can-lead-to-a-range-of-thyroid-conditions","title":{"rendered":"Germline mutations in DICER1 and DGCR8 can lead to a range of thyroid conditions"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/germline-mutations-in-dicer1-and-dgcr8-can-lead-to-a-range-of-thyroid-conditions2.jpg\"><\/a><\/p>\n<p>Here, Barbara Rivera &amp; team report on the benign-to-malignant progression route in <i><i>DICER1<\/i>\/DGCR8<\/i>-thyroid lesions, identifying a <i><i>DICER1<\/i>-<\/i>cancer epi-signature using multi-omic profiling:<\/p>\n<p>The image depicts a thyroid lesion from a sporadic <i>DICER1<\/i> case with immunofluorescent staining for pan-cytokeratin (green) and vimentin (red). Enclosed areas represent selected regions of interest.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Program in Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell), Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, Barcelona, Spain.<\/p>\n<p><sup>2<\/sup>Genetics Program, Faculty of Biology, and.<\/p>\n<p><sup>3<\/sup>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here, Barbara Rivera &amp; team report on the benign-to-malignant progression route in DICER1\/DGCR8-thyroid lesions, identifying a DICER1-cancer epi-signature using multi-omic profiling: The image depicts a thyroid lesion from a sporadic DICER1 case with immunofluorescent staining for pan-cytokeratin (green) and vimentin (red). Enclosed areas represent selected regions of interest. 1Program in Molecular Mechanisms and Experimental Therapy [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-231557","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231557"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231557\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231557"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231557"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}