{"id":231534,"date":"2026-02-17T14:16:42","date_gmt":"2026-02-17T20:16:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/senescent-astrocytes-discovered-in-alzheimers-brains-point-to-new-treatment-targets"},"modified":"2026-02-17T14:16:42","modified_gmt":"2026-02-17T20:16:42","slug":"senescent-astrocytes-discovered-in-alzheimers-brains-point-to-new-treatment-targets","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/senescent-astrocytes-discovered-in-alzheimers-brains-point-to-new-treatment-targets","title":{"rendered":"Senescent astrocytes discovered in Alzheimer\u2019s brains point to new treatment targets"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/senescent-astrocytes-discovered-in-alzheimers-brains-point-to-new-treatment-targets2.jpg\"><\/a><\/p>\n<p>Researchers from the NeuroAD group (Neuropathology of Alzheimer\u2019s Disease) within the Department of Cell Biology, Genetics and Physiology at the University of M\u00e1laga, also affiliated with IBIMA\u2013BIONAND Platform and CIBERNED, have made a pioneering breakthrough in the fight against this disease by identifying astrocytes as a promising cellular target for the development of future therapies.<\/p>\n<p>The study demonstrates, for the first time, the presence of senescent astrocytes\u2014cells that remain alive but have lost their functional capacity\u2014in the brains of Alzheimer\u2019s patients, positioning this cellular aging process as a key mechanism in neurodegeneration.<\/p>\n<p>The research, <a href=\"https:\/\/link.springer.com\/10.1186\/s12974-025-03607-z\" target=\"_blank\">published<\/a> in the journal <i>Journal of Neuroinflammation<\/i>, was led by Dr. Antonia Guti\u00e9rrez, Professor of Cell Biology and Principal Investigator of the NeuroAD group, together with Dr. Juan Antonio Garc\u00eda Le\u00f3n, Associate Professor of Cell Biology. Other contributors to the study include Laura C\u00e1ceres, Laura Trujillo, Elba L\u00f3pez, Elisabeth S\u00e1nchez, and In\u00e9s Moreno.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from the NeuroAD group (Neuropathology of Alzheimer\u2019s Disease) within the Department of Cell Biology, Genetics and Physiology at the University of M\u00e1laga, also affiliated with IBIMA\u2013BIONAND Platform and CIBERNED, have made a pioneering breakthrough in the fight against this disease by identifying astrocytes as a promising cellular target for the development of future therapies. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269,47],"tags":[],"class_list":["post-231534","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231534"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231534\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}