{"id":231473,"date":"2026-02-16T21:11:22","date_gmt":"2026-02-17T03:11:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/srebp-1-upregulates-soat1-to-promote-tumor-growth-by-preventing-lipotoxicity"},"modified":"2026-02-16T21:11:22","modified_gmt":"2026-02-17T03:11:22","slug":"srebp-1-upregulates-soat1-to-promote-tumor-growth-by-preventing-lipotoxicity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/srebp-1-upregulates-soat1-to-promote-tumor-growth-by-preventing-lipotoxicity","title":{"rendered":"SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/srebp-1-upregulates-soat1-to-promote-tumor-growth-by-preventing-lipotoxicity2.jpg\"><\/a><\/p>\n<p>Zhong et al. demonstrate that <i>SREBP-1<\/i> and SOAT1 are co-upregulated in GBM and NSCLC, coupling cholesterol acquisition and storage. They reveal that <i>SREBP-1<\/i> transcriptionally activates SOAT1, enabling cancer cells to sustain cholesterol homeostasis, and that targeting SOAT1 disrupts this balance, leading to ROS accumulation, mitochondrial dysfunction, and tumor cell death.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhong et al. demonstrate that SREBP-1 and SOAT1 are co-upregulated in GBM and NSCLC, coupling cholesterol acquisition and storage. They reveal that SREBP-1 transcriptionally activates SOAT1, enabling cancer cells to sustain cholesterol homeostasis, and that targeting SOAT1 disrupts this balance, leading to ROS accumulation, mitochondrial dysfunction, and tumor cell death.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-231473","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231473","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231473"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231473\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231473"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231473"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231473"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}