{"id":231443,"date":"2026-02-16T10:18:58","date_gmt":"2026-02-16T16:18:58","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/a-jagged1-regulated-hybrid-emt-state-identifies-pancreatic-cancer-stem-cells"},"modified":"2026-02-16T10:18:58","modified_gmt":"2026-02-16T16:18:58","slug":"a-jagged1-regulated-hybrid-emt-state-identifies-pancreatic-cancer-stem-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/a-jagged1-regulated-hybrid-emt-state-identifies-pancreatic-cancer-stem-cells","title":{"rendered":"A Jagged1-regulated hybrid-EMT state identifies pancreatic cancer stem cells"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-jagged1-regulated-hybrid-emt-state-identifies-pancreatic-cancer-stem-cells.jpg\"><\/a><\/p>\n<p>Lan et al. show that a subset of CD9hi tumor-initiating cells in pancreatic cancer exhibits hybrid-EMT features and possesses enhanced self-renewal and differentiation capacities. Depletion of these cells or blockage of Jagged1-Notch signaling impairs tumorigenesis and cellular heterogeneity, revealing a vulnerability for pancreatic cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lan et al. show that a subset of CD9hi tumor-initiating cells in pancreatic cancer exhibits hybrid-EMT features and possesses enhanced self-renewal and differentiation capacities. Depletion of these cells or blockage of Jagged1-Notch signaling impairs tumorigenesis and cellular heterogeneity, revealing a vulnerability for pancreatic cancer.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-231443","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231443"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231443\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}