{"id":231402,"date":"2026-02-15T13:13:33","date_gmt":"2026-02-15T19:13:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/dimerization-dependent-gel-like-condensation-with-dsdna-underpins-the-activation-of-human-cgas"},"modified":"2026-02-15T13:13:33","modified_gmt":"2026-02-15T19:13:33","slug":"dimerization-dependent-gel-like-condensation-with-dsdna-underpins-the-activation-of-human-cgas","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/dimerization-dependent-gel-like-condensation-with-dsdna-underpins-the-activation-of-human-cgas","title":{"rendered":"Dimerization-dependent gel-like condensation with dsDNA underpins the activation of human cGAS"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/dimerization-dependent-gel-like-condensation-with-dsdna-underpins-the-activation-of-human-cgas2.jpg\"><\/a><\/p>\n<p>CGAS forms condensates on cytosolic double-stranded (ds)DNA and initiates inflammatory responses. Lueck et al. find that, although cGAS forms condensates on various nucleic acids, it enters a hydrogel-like state only with dsDNA via dimerization. The gel-like cGAS condensate not only protects bound dsDNA from exonucleases but also facilitates catalysis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CGAS forms condensates on cytosolic double-stranded (ds)DNA and initiates inflammatory responses. Lueck et al. find that, although cGAS forms condensates on various nucleic acids, it enters a hydrogel-like state only with dsDNA via dimerization. The gel-like cGAS condensate not only protects bound dsDNA from exonucleases but also facilitates catalysis.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1635],"tags":[],"class_list":["post-231402","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-materials"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231402","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231402"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231402\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231402"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231402"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}