{"id":231373,"date":"2026-02-14T21:13:34","date_gmt":"2026-02-15T03:13:34","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/c9orf72-in-myeloid-cells-prevents-an-inflammatory-response-to-microbial-glycogen"},"modified":"2026-02-14T21:13:34","modified_gmt":"2026-02-15T03:13:34","slug":"c9orf72-in-myeloid-cells-prevents-an-inflammatory-response-to-microbial-glycogen","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/c9orf72-in-myeloid-cells-prevents-an-inflammatory-response-to-microbial-glycogen","title":{"rendered":"C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/c9orf72-in-myeloid-cells-prevents-an-inflammatory-response-to-microbial-glycogen2.jpg\"><\/a><\/p>\n<p>Factors that promote inflammation in <i>C9ORF72<\/i> mutation carriers with amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) have remained elusive. McCourt et al. identified pro-inflammatory forms of glycogen in gut contents of people with ALS\/FTD and demonstrate that targeting glycogen in a <i>C9orf72<\/i> mouse model extends lifespan and reduces neuroinflammation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Factors that promote inflammation in C9ORF72 mutation carriers with amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) have remained elusive. McCourt et al. identified pro-inflammatory forms of glycogen in gut contents of people with ALS\/FTD and demonstrate that targeting glycogen in a C9orf72 mouse model extends lifespan and reduces neuroinflammation.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269,47],"tags":[],"class_list":["post-231373","post","type-post","status-publish","format-standard","hentry","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231373"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231373\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}