{"id":231365,"date":"2026-02-14T17:13:27","date_gmt":"2026-02-14T23:13:27","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/abstract-how-does-diabetes-exacerbate-periodontal-disease"},"modified":"2026-02-14T17:13:27","modified_gmt":"2026-02-14T23:13:27","slug":"abstract-how-does-diabetes-exacerbate-periodontal-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/abstract-how-does-diabetes-exacerbate-periodontal-disease","title":{"rendered":"Abstract: How does diabetes exacerbate periodontal disease?"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract71.jpg\"><\/a><\/p>\n<p>Dana T. Graves &amp; team identify the CD137L\/CD137 axis as a pivotal mediator of diabetes-induced inflammatory tissue destruction, in which dendritic cell produced CD137L activates \u03b3\u03b4 T-cells through CD137, leading to a dysregulated host response and worsening damage from bacterial challenge:<\/p>\n<p>The figure shows microCT images of 3D reconstruction of the molar teeth from mouse models of periodontitis injected with control, CD137L-agonist, CD137L-antagonist antibodies.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Hospital of Stomatology, Guanghua School of Stomatology and.<\/p>\n<p><sup>2<\/sup>Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.<\/p>\n<p><sup>3<\/sup>Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dana T. Graves &amp; team identify the CD137L\/CD137 axis as a pivotal mediator of diabetes-induced inflammatory tissue destruction, in which dendritic cell produced CD137L activates \u03b3\u03b4 T-cells through CD137, leading to a dysregulated host response and worsening damage from bacterial challenge: The figure shows microCT images of 3D reconstruction of the molar teeth from mouse [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-231365","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231365"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231365\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}